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Fralanyzer identifies functional residues in a query sequence by analyzing the conservation of functionally significant residues in a query-template alignment obtained from the fold recognition servers Bioinfo or INUB, or from a user defined alignment. It can also identifies functional residues in a query structure based on the structural alignments obtained from the VAST server or from a user defined structural alignment. The functionally important residues (such as active site residues, DNA, metal or ligand binding residues, prosite patterns) for the template and related sequences are obtained from the PDBSum database using SAS facility.
It also allows users to obtain functional annotations from the SwissProt database for both the query and template sequences. Further, users can search the query sequence against the COG database, predict structural domains using the Meta-DP domain prediction meta server and predict Gene Ontology (GO) terms for query using Meta-GO server.
For detailed methodology and further information, please see the Fralanyzer documentation file and our Sample Examples. |
| Please send any suggestions or queries to Harpreet Kaur Saini |